Hi,
I’ve been a MySQL admin for 25 years. Whatever source you’re reading that is telling you that autoloaded options in the database is slowing down your home page is wrong. The difference is immeasurably small; the ‘autoload’ column is indexed and the data size is tiny. You can ascertain that yourself by making them not-auto-load, e.g. with a query like (change the table prefix appropriately);;
UPDATE wp_options SET autoload='no' WHERE option_name LIKE 'updraft%'
This will make no measurable difference to your front-end. It may make measurable difference to loading the UpdraftPlus settings page (depending on your database server), because now WordPress will issue a few dozen individual SQL queries instead of one aggregated query.
If your front-end is slow, you need to look elsewhere. If you have autoloaded options with large quantities of data in (e.g. totalling millions of bytes, i.e. measured in Megabytes), then certainly, attack those. But UD settings are typically a counted in single bytes, or tens of bytes, which is immeasurable in impact.
David